Cefadian - Avita Farma

May 1, 2018 | Author: Anonymous | Category: N/A
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Active ingredient: Dry extract from Silverweed

Indication: Dysmenorrhea

Silverweed - gentle and natural in case of dysmenorrhea The so-called dysmenorrhea is a painful menstruation and is widespread. Especially young girls and women aged between 14 and 25 are suffering from this menstrual disorder. The complaints, mostly spasmodic, in the hypogastric region can radiate into the back and the legs. Moreover, there are complaints such as nausea, vomiting, headache, migraine and mental depressive moods. Here, the therapy is directed to the causes: in addition to synthetic spasmolytics, analgesics or hormones are used.

Botany Potentilla anserina L. Family:

Rosaceae (rose plants)


Crampweed, Goosegrass, Prince's feathers


Spread in the mostly colder zones of the entire northern hemisphere.

Medicinal drug: Potentillae anserinae herba (Silverweed), the dried overground plant parts collected during time of prosperity.

Brief profile - Silverweed 

Enduring, low, creeping plant

Up to 15 cm high

Pinnate, dark green leaves, on the bottom

silvery hair 

Golden yellow flowers on long stems

Time of prosperity: May to August

Pharmacology Ingredients determining efficacy 

   

tanning agents tormentoside flavonoids anthocyans phytosterols

Effects   

spasmolytic analgetic normalises contraction frequency of the uterus

Pharmacology Mechanism of action Intervention in the hypothalamic-hypophyseal circuit of regulation is excluded.  effect of dry extract form Silverweed probably via direct attack at the smooth musculature of the uterus  inhibiting effect on prostaglandin synthesis

Toxicology In cavies and rabbits 3.1 - 6.2 g drug respectively 0.78 - 1.56 g extract did not show any evidences of a harmful effect (Bliss 1940).

Clinical efficacy Dysmenorrhea The good antidysmenorrheic effect of Silverweed is verified clinically. In studies it was found out that Silverweed has a marked spasmolytic effect on the uterus. In experiments with animals, spasmolytic effects on the smooth musculature of uterus and intestines could be verified, too.

Proven therapeutic success with Cefadian® Cefadian® - multicentre field study Therapy of dysmenorrheic complaints with a herbal remedy; a multicentre field study. Schauerte W, (1993): Jatros Gynäkologie 9 (6)

Indication: Examination period: Patient collective: Age: Medication:

dysmenorrheic complaints 8 weeks 97 female patients 14-53 years 2 tablets 2-3 times daily

Proven therapeutic success with Cefadian® Multicentre field study

 very good tolerability  healing and improvement rates of more than 85% (mainly abdominal pain and backache)

 good alternative to analgesics and/or hormones in case of slight and moderate dysmenorrheic complaints

Proven therapeutic success with Cefadian® Multicentre field study

Chart 1: score average values at the individual examination times 1 = none, 2 = slight, 3 = moderate, 4 = severe

Proven therapeutic success with Cefadian®

Fig. 1: Cefadian® - progress of the complaints (score reduction at the individual examination times)

Tolerability Irritable stomach disorders can aggravate. The side effects can probably be attributed to the contained tanning agents.

Cefadian® advantages at a glance 

spasmolytic effect

analgetic effect

herbal alternative to analgesics / hormones

natural and gentle

Basic information Field of application Slight dysmenorrheic complaints (disorders during menstruation). Composition 1 film coated tablet contains: Active ingredient: Dry extract from Anserinae herba (5 : 1) 200 mg Excipients: Lactose monohydrate, povidone, magnesium stearate, macrogol, titanium dioxide (E171), hypromellose, talc, polyacrylate, ferric oxide (E172), cellulose powdered. Contra-indications None known. Interaction with other substances None known.

Basic information Dosage Unless otherwise prescribed, adults and adolescents take 2 tablets 2 - 3 times daily. Kind and duration of application Cefadian® film coated tablets are taken without chewing with some liquid (e.g. water). It would be reasonable to start intake some days before the expected onset of the menstruation and to continue it for 3 to 4 days after disappearance of the complaints. In especially obstinate cases a daily intake over several cycles is possible. Duration of the application is not limited. Side effects Irritable stomach disorders can aggravate. Commercial form Film coated tablets: 50 pcs.

Monograph Potentilla, Potentillae anserinae herba Official Monograph of the Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) (German Federal Institute for Drugs and Medical Devices) Commission E (Phytotherapy), BAnz.-No. 223 dated November 30, 1985, revised March 13, 1990

Name of Drug Potentillae anserinae herba, potentilla, silverweed. Composition of Drug Potentilla herb consists of the fresh or dried leaf and flowers of Potentilla anserine L., [Fam. Rosaceae], harvested shortly before or during flowering, as well as its preparations in effective dosage. The herb contains at least 2 percent tannins when precipitated with casein, calculated as gallic acid (C7H6 O5, MW 170.1) and related to the dried herb. Other ingredients are tormentoside, phytosterols, flavonoids and anthocyanins. Uses Mild dysmenorrheal disorders, support for treatment of milder, nonspecific, acute diarrhea, light inflammation of the oral and pharyngeal mucosa.

Monograph Contraindications None known. Side Effects Gastric irritations could be aggravated. Interactions with Other Drugs None known. Dosage Daily dosage: 4 – 6 g of herb; equivalent preparations. Mode of Administration Cut herb for infusions and decoctions. Powdered herb and other galenical preparations for oral use. Actions Astringent, depending on tannin concentration. Distinct increase in tonus and contraction frequency on the isolated uterus of various animals.

Differentiation in the area of dysmenorrhoea – PMS (Cefadian® / Cefanorm®) Cefadian®


• girls / young women, 14- 25

• grown-up women over 25

(up to an age of 30) • no children • dysmenorrhoea • (increased prostaglandin)

• does often have children • PMS • (imbalance estrogen/progesterone)

• most intensive on 1st day of menstruation

• complaints during the last 10 days of the cycle

• colic-like lower abdominal pain

• lower abdominal pain + mastodynia

general accompanying symptoms such as nausea, backache, headache, mental depressive moods

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